Contents
Vol 2, Issue 87
Contents
Research Articles
- Rapid Evolution of Functional Complexity in a Domain Family
Synthetic PDZ domain variants with random mutations reveal the remarkable robustness of this domain for ligand recognition.
- Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6
Regulator of chromosome condensation–2 is a component of fibronectin-activated signaling pathways that regulate cell migration.
- The Tyrosine Kinase Fer Is a Downstream Target of the PLD-PA Pathway that Regulates Cell Migration
Changes in membrane composition stimulate Fer activity to regulate actin remodeling and drive cell migration.
Review
- Oncogenic EGFR Signaling Networks in Glioma
EGFR and downstream signaling networks contribute to the hallmark characteristics of glioma.
Podcast
- Science Signaling Podcast: 8 September 2009
Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities.
Editors' Choice
- Bone-Building T Cells
T cells release Wnt10b in response to intermittent parathyroid hormone to stimulate bone formation.
- cAMP Signaling Timer
The cAMP pathway appears to mediate both activation and deactivation of the transcription factor Phox2a.
- Reining in Tumor Suppression
Cancer cell growth is stimulated by the inhibition of a previously unknown step in cell signaling for tumor suppression.
- Damage, Signal, Maneuver
A chromatin remodeling complex targeted by poly(ADP ribosyl)ation plays a role in DNA repair.
- Epigenetic Signals
A phospholipid that binds to nuclear enzymes modifies gene transcription in response to external stimuli.
- Fascin-Actin Rab Bristles
Development of sensory bristles in flies depends on controlling the colocalization of actin assembly on membranes.
- Tissue Damage Sensor
Release of a proteoglycan at sites of tissue damage can activate the innate immune system.