Contents

Contents

• Research Articles

  • Rapid Evolution of Functional Complexity in a Domain Family

    By Andreas Ernst, Stephen L. Sazinsky, Shirley Hui, Bridget Currell, Moyez Dharsee, Somasekar Seshagiri, Gary D. Bader, Sachdev S. Sidhu

    Science Signaling08 Sep 2009 : ra50 Full AccessRestricted Access

    Synthetic PDZ domain variants with random mutations reveal the remarkable robustness of this domain for ligand recognition.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

    By Jonathan D. Humphries, Adam Byron, Mark D. Bass, Sue E. Craig, John W. Pinney, David Knight, Martin J. Humphries

    Science Signaling08 Sep 2009 : ra51 Full AccessRestricted Access

    Regulator of chromosome condensation–2 is a component of fibronectin-activated signaling pathways that regulate cell migration.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • The Tyrosine Kinase Fer Is a Downstream Target of the PLD-PA Pathway that Regulates Cell Migration

    By Toshiki Itoh, Junya Hasegawa, Kazuya Tsujita, Yasunori Kanaho, Tadaomi Takenawa

    Science Signaling08 Sep 2009 : ra52 Full AccessRestricted Access

    Changes in membrane composition stimulate Fer activity to regulate actin remodeling and drive cell migration.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Review

  • Oncogenic EGFR Signaling Networks in Glioma

    By Paul H. Huang, Alexander M. Xu, Forest M. White

    Science Signaling08 Sep 2009 : re6 Full AccessRestricted Access

    EGFR and downstream signaling networks contribute to the hallmark characteristics of glioma.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 8 September 2009

    By Sachdev S. Sidhu, Annalisa M. VanHook

    Science Signaling08 Sep 2009 : pc16 Full AccessRestricted Access

    Synthetic PDZ domain variants reveal how this domain can evolve to produce proteins with different binding specificities.

    • Abstract
    • Full Text

• Editors' Choice

  • Bone-Building T Cells

    By Wei Wong

    Science Signaling08 Sep 2009 : ec295 Full AccessRestricted Access

    T cells release Wnt10b in response to intermittent parathyroid hormone to stimulate bone formation.

    • Abstract

  • cAMP Signaling Timer

    By Nancy R. Gough

    Science Signaling08 Sep 2009 : ec296 Full AccessRestricted Access

    The cAMP pathway appears to mediate both activation and deactivation of the transcription factor Phox2a.

    • Abstract

  • Reining in Tumor Suppression

    By L. Bryan Ray

    Science Signaling08 Sep 2009 : ec297 Full AccessRestricted Access

    Cancer cell growth is stimulated by the inhibition of a previously unknown step in cell signaling for tumor suppression.

    • Abstract

  • Damage, Signal, Maneuver

    By Guy Riddihough

    Science Signaling08 Sep 2009 : ec298 Full AccessRestricted Access

    A chromatin remodeling complex targeted by poly(ADP ribosyl)ation plays a role in DNA repair.

    • Abstract

  • Epigenetic Signals

    By L. Bryan Ray

    Science Signaling08 Sep 2009 : ec299 Full AccessRestricted Access

    A phospholipid that binds to nuclear enzymes modifies gene transcription in response to external stimuli.

    • Abstract

  • Fascin-Actin Rab Bristles

    By Stella M. Hurtley

    Science Signaling08 Sep 2009 : ec300 Full AccessRestricted Access

    Development of sensory bristles in flies depends on controlling the colocalization of actin assembly on membranes.

    • Abstract

  • Tissue Damage Sensor

    By L. Bryan Ray

    Science Signaling08 Sep 2009 : ec301 Full AccessRestricted Access

    Release of a proteoglycan at sites of tissue damage can activate the innate immune system.

    • Abstract