Research ArticleCell Biology Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6 Jonathan D. Humphries1,2,*, Adam Byron1,2,*, Mark D. Bass1,2, Sue E. Craig1,2, John W. Pinney2,†, David Knight2, and Martin J. Humphries1,2,‡1Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.2Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.↵‡To whom correspondence should be addressed. E-mail: martin.humphries{at}manchester.ac.uk ↵* These authors contributed equally to this work. ↵† Present address: Centre for Bioinformatics, Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK. See allHide authors and affiliations Science Signaling 08 Sep 2009:Vol. 2, Issue 87, pp. ra51DOI: 10.1126/scisignal.2000396 Jonathan D. Humphries 1Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.2Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Adam Byron 1Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.2Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Mark D. Bass 1Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.2Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sue E. Craig 1Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.2Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site John W. Pinney 2Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site David Knight 2Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Martin J. Humphries 1Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.2Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: martin.humphries@manchester.ac.uk Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 2 no. 87 ra51 DOI: https://doi.org/10.1126/scisignal.2000396 PubMed: 19738201 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received April 24, 2009Accepted August 20, 2009 . 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Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6 By Jonathan D. Humphries, Adam Byron, Mark D. Bass, Sue E. Craig, John W. Pinney, David Knight, Martin J. Humphries Science Signaling08 Sep 2009 : ra51 Regulator of chromosome condensation–2 is a component of fibronectin-activated signaling pathways that regulate cell migration.
Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6 By Jonathan D. Humphries, Adam Byron, Mark D. Bass, Sue E. Craig, John W. Pinney, David Knight, Martin J. Humphries Science Signaling08 Sep 2009 : ra51 Regulator of chromosome condensation–2 is a component of fibronectin-activated signaling pathways that regulate cell migration.