Contents

Contents

• Research Articles

  • Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

    By Begoña Diaz, Gidon Shani, Ian Pass, Diana Anderson, Manuela Quintavalle, Sara A. Courtneidge

    Science Signaling15 Sep 2009 : ra53 Full AccessRestricted Access

    Localized production of reactive oxygen species is key for cellular invasiveness and may be involved in a positive feedback loop with proteins that organize their site of production.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Novel p47^phox-Related Organizers Regulate Localized NADPH Oxidase 1 (Nox1) Activity

    By Davide Gianni, Begoña Diaz, Nicolas Taulet, Bruce Fowler, Sara A. Courtneidge, Gary M. Bokoch

    Science Signaling15 Sep 2009 : ra54 Full AccessRestricted Access

    Tks proteins, which are Src substrates, control the localized production of reactive oxygen species by Nox.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis

    By Helen P. Makarenkova, Matthew P. Hoffman, Andrew Beenken, Anna V. Eliseenkova, Robyn Meech, Cindy Tsau, Vaishali N. Patel, Richard A. Lang, Moosa Mohammadi

    Science Signaling15 Sep 2009 : ra55 Full AccessRestricted Access

    Manipulation of the interaction of a morphogen with the extracellular matrix changes its biological activities by altering its diffusion.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspectives

  • Regulation of Cancer Invasion by Reactive Oxygen Species and Tks Family Scaffold Proteins

    By Alissa M. Weaver

    Science Signaling15 Sep 2009 : pe56 Full AccessRestricted Access

    Tks proteins organize NADPH oxidase activity and localized production of reactive oxygen species in invasive cells.

    • Abstract
    • Full Text
    • PDF

  • Endocannabinoids Can Open the Pain Gate

    By MacDonald J. Christie, Christophe Mallet

    Science Signaling15 Sep 2009 : pe57 Full AccessRestricted Access

    Endocannabinoids generated in the spinal cord can enhance pain responses instead of relieving pain.

    • Abstract
    • Full Text
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• Editors' Choice

  • Come and Find Me

    By John F. Foley

    Science Signaling15 Sep 2009 : ec302 Full AccessRestricted Access

    ATP and UTP released from apoptotic cells recruit the macrophages necessary for their clearance.

    • Abstract

  • It’s a Gas

    By Caroline Ash

    Science Signaling15 Sep 2009 : ec303 Full AccessRestricted Access

    Bacteria deploy nitric oxide synthases to counter oxidative stress from natural toxins and antibiotic drugs.

    • Abstract

  • Not Constitutively Active After All?

    By Nancy R. Gough

    Science Signaling15 Sep 2009 : ec304 Full AccessRestricted Access

    Comparison of the structure of ErbB2 with Drosophila epidermal growth factor receptor suggests that both may be autoinhibited in the absence of ligand.

    • Abstract

  • Crystal Clear

    By L. Bryan Ray

    Science Signaling15 Sep 2009 : ec305 Full AccessRestricted Access

    Crystal structures reveal the mechanism of a nucleotide exchange factor regulating cytoskeleton and cell signaling networks.

    • Abstract

  • A New Dawn for Neurite Growth?

    By Elizabeth M. Adler

    Science Signaling15 Sep 2009 : ec306 Full AccessRestricted Access

    The mitotic kinase Aurora A regulates microtubule dynamics during neurite extension.

    • Abstract

  • Initiating Myelination

    By Annalisa M. VanHook

    Science Signaling15 Sep 2009 : ec307 Full AccessRestricted Access

    An orphan G protein–coupled receptor is required in Schwann cells to trigger myelination.

    • Abstract

  • The Cilium as a Moving Target for Cancer Therapy

    By L. Bryan Ray

    Science Signaling15 Sep 2009 : ec308 Full AccessRestricted Access

    Loss of primary cilia can promote or inhibit cancers dependent on hedgehog signaling.

    • Abstract