Contents
Vol 2, Issue 88
Contents
Research Articles
- Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation
Localized production of reactive oxygen species is key for cellular invasiveness and may be involved in a positive feedback loop with proteins that organize their site of production.
- Novel p47phox-Related Organizers Regulate Localized NADPH Oxidase 1 (Nox1) Activity
Tks proteins, which are Src substrates, control the localized production of reactive oxygen species by Nox.
- Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis
Manipulation of the interaction of a morphogen with the extracellular matrix changes its biological activities by altering its diffusion.
Perspectives
- Regulation of Cancer Invasion by Reactive Oxygen Species and Tks Family Scaffold Proteins
Tks proteins organize NADPH oxidase activity and localized production of reactive oxygen species in invasive cells.
- Endocannabinoids Can Open the Pain Gate
Endocannabinoids generated in the spinal cord can enhance pain responses instead of relieving pain.
Editors' Choice
- Come and Find Me
ATP and UTP released from apoptotic cells recruit the macrophages necessary for their clearance.
- It’s a Gas
Bacteria deploy nitric oxide synthases to counter oxidative stress from natural toxins and antibiotic drugs.
- Not Constitutively Active After All?
Comparison of the structure of ErbB2 with Drosophila epidermal growth factor receptor suggests that both may be autoinhibited in the absence of ligand.
- Crystal Clear
Crystal structures reveal the mechanism of a nucleotide exchange factor regulating cytoskeleton and cell signaling networks.
- A New Dawn for Neurite Growth?
The mitotic kinase Aurora A regulates microtubule dynamics during neurite extension.
- Initiating Myelination
An orphan G protein–coupled receptor is required in Schwann cells to trigger myelination.
- The Cilium as a Moving Target for Cancer Therapy
Loss of primary cilia can promote or inhibit cancers dependent on hedgehog signaling.