Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis

Helen P. Makarenkova; Matthew P. Hoffman; Andrew Beenken; Anna V. Eliseenkova; Robyn Meech; Cindy Tsau; Vaishali N. Patel; Richard A. Lang; Moosa Mohammadi

doi:10.1126/scisignal.2000304

Research ArticleMorphogenesis

Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis

Helen P. Makarenkova¹,²,*,†,
Matthew P. Hoffman³,*,
Andrew Beenken⁴,
Anna V. Eliseenkova⁴,
Robyn Meech²,⁵,
Cindy Tsau¹,
Vaishali N. Patel³,
Richard A. Lang⁶, and
Moosa Mohammadi⁴,*

¹The Neurobiology Department, The Scripps Research Institute, La Jolla, CA 92037, USA.
²The Neurosciences Institute, San Diego, CA 92121, USA.
³Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
⁴Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
⁵Department of Clinical Pharmacology, Flinders University, Bedford Park, South Australia 5042, Australia.
⁶The Visual Systems Group, Department of Ophthalmology and Division of Developmental Biology, Children’s Hospital Research Foundation, Cincinnati, OH 45229, USA.

↵†To whom correspondence should be addressed. E-mail: hmakarenk{at}scripps.edu

↵* These authors contributed equally to this work.

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Science Signaling 15 Sep 2009:
Vol. 2, Issue 88, pp. ra55
DOI: 10.1126/scisignal.2000304

Helen P. Makarenkova

1The Neurobiology Department, The Scripps Research Institute, La Jolla, CA 92037, USA.

2The Neurosciences Institute, San Diego, CA 92121, USA.

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For correspondence: hmakarenk@scripps.edu

Matthew P. Hoffman

3Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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Andrew Beenken

4Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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Anna V. Eliseenkova

4Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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Robyn Meech

2The Neurosciences Institute, San Diego, CA 92121, USA.

5Department of Clinical Pharmacology, Flinders University, Bedford Park, South Australia 5042, Australia.

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Cindy Tsau

1The Neurobiology Department, The Scripps Research Institute, La Jolla, CA 92037, USA.

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Vaishali N. Patel

3Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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Richard A. Lang

6The Visual Systems Group, Department of Ophthalmology and Division of Developmental Biology, Children’s Hospital Research Foundation, Cincinnati, OH 45229, USA.

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Moosa Mohammadi

4Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis

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