Contents
Vol 2, Issue 89
Contents
Research Articles
- The Single Transmembrane Domains of Human Receptor Tyrosine Kinases Encode Self-Interactions
The transmembrane domain of any of the 58 human receptor tyrosine kinases is sufficient to mediate dimerization.
- MSK2 Inhibits p53 Activity in the Absence of Stress
The kinase MSK2 inhibits p53 transcriptional activity at a subset of promoters through a kinase-independent mechanism.
Perspectives
- Integrin Proteomes Reveal a New Guide for Cell Motility
A proteomics analysis of integrin-associated complexes establishes an unexpected connection to cell migration.
- Human-Specific Genes May Offer a Unique Window into Human Cell Signaling
Analysis of human-specific genes may reveal, at the molecular level, what makes humans human.
Editors' Choice
- His and Hers Receptors
Related receptor-like tyrosine kinases are differentially required in male and female gametophytes for fertilization.
- Channel Shutdown
A viral protein inhibits the function of a K+ channel to prevent infected cells from undergoing apoptosis.
- Paths to Resistance
A mouse cancer model reveals genes that, when mutated, promote drug resistance in leukemias caused by excessive signaling through the Ras-MAPK pathway.
- Desperately Seeking Glucose
Glucose deprivation can drive the acquisition of certain oncogenic mutations in human cancer cells.
- Negative Guidance System
Neutralization of vascular endothelial growth factor by its soluble receptor provides guidance cues during sprouting angiogenesis.
- Anyone for D?
Bacteria produce d-amino acids to regulate their cell wall composition, structure, amount, and strength.
- A Separate System for Itch Processing
Itch, but not pain sensation, is abolished by selective ablation of a small subpopulation of spinal neurons.
- BMP15 Mutants Lose Their Heads
Inhibitory effects of bone morphogenetic protein 15 may explain effects on development and adult infertility.
Errata
