Contents
Vol 2, Issue 91
Contents
Research Articles
- Wingless Promotes Proliferative Growth in a Gradient-Independent Manner
Proliferation of cells in the Drosophila wing does not require a gradient of the morphogen Wingless.
- Coordinated Responses to Oxygen and Sugar Deficiency Allow Rice Seedlings to Tolerate Flooding
The protein kinase CIPK15 integrates the response to hypoxia with sugar signaling to allow submerged rice seedlings to grow.
Perspectives
- Apoptosis: Calling Time on Apoptosome Activity
Caspase-9 autoprocessing displaces active caspase-9 bound to the apoptosome, thereby limiting proteolytic activity.
- Snapshots Form a Big Picture of Guanine Nucleotide Exchange
DOCK9 uses a unique mechanism to discriminate between GDP- and GTP-bound forms of Cdc42.
Podcast
- Science Signaling Podcast: 6 October 2009
Graded distribution of Wingless is not required for cell proliferation in the fly wing disc.
Editors' Choice
- Nicotine Irritation
Treatments to stop smoking contain nicotine at concentrations sufficient to activate TRPA1 channels, which contribute to irritation.
- Cholesterol Signals
The Toll-like receptor–dependent release of 25-hydroxycholesterol by macrophages inhibits the production of IgA by B cells.
- Inhibiting Wnt Signaling
Tankyrases are previously unknown components of the Wnt signaling pathway that may provide opportunities for therapeutic intervention in Wnt-dependent cancers.
- Mimicking Caloric Restriction
A signaling pathway in mice mediates the effects of caloric restriction that protect against age-related diseases.
- Stemming Displacement
Negative feedback of JAK-STAT signaling prevents somatic stem cells from outcompeting germline stem cells in the fly testis.
- Dog Coats Shed Genetic Secrets
Huge variations in the coats of purebred dogs can be explained by the combinatorial effects of only three genes.
