Contents
Vol 2, Issue 92
Contents
Research Articles
- MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells
Akt-dependent induction of a metastatic phenotype may depend on the balance of Akt1 and Akt2.
- Act1, a U-box E3 Ubiquitin Ligase for IL-17 Signaling
The adaptor protein Act1 functions as a ubiquitin ligase to mediate interleukin-17 receptor–dependent activation of nuclear factor-κB.
- Chemical Genetics Identifies c-Src as an Activator of Primitive Ectoderm Formation in Murine Embryonic Stem Cells
Kinases engineered for inhibitor resistance reveal a unique role for c-Src in embryonic stem cell differentiation.
Perspective
- IL-17 Receptor Signaling: Ubiquitin Gets In On the Act
Ubiquitin ligase can be added to the functions of Act1 as it mediates IL-17 signaling.
Podcast
- Science Signaling Podcast: 13 October 2009
Distinct Src kinases regulate the differentiation of embryonic stem cells.
Editors' Choice
- Stressful Bone Building
The ER stress transducer OASIS is required for BMP2-dependent bone formation by osteoblasts.
- JAK Goes Nuclear
Nuclear JAK2 protein kinase controls gene expression through modification of chromatin.
- Breaching a Barrier
AMPK plays a role in the increase in permeability of the intestinal epithelial barrier mediated by IFN-γ.
- Gas and Brakes Required
The ability of land plants to sense and respond to cytokinins co-evolved with a mechanism for attenuating cytokinin signaling.
- The Sensitive Side of ROS
Reactive oxygen species promote PTEN oxidation, PI3K signaling, and insulin sensitivity in muscle.
- Peeking at Pathogen Response Networks
Inflammatory and antiviral programs in dendritic cells are controlled and tuned by a network of regulators.
- Quiet Clock
Clock-containing neurons in the mouse brain display complex electrophysiology not seen in other brain cells.
- Making Split Decisions
An alternative developmental pathway for vertebrate vasculature segregates a precursor vessel into two separate vessels.
