Research ArticleCancer

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells

See allHide authors and affiliations

Science Signaling  13 Oct 2009:
Vol. 2, Issue 92, pp. ra62
DOI: 10.1126/scisignal.2000356

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Balance Is Everything

Members of the Akt family of protein kinases, which are activated by growth factor signaling, have been implicated in human cancer; however, the different Akt isoforms appear to play distinct roles. Iliopoulos et al. used cells containing only a single Akt isoform—or cells in which the abundance of one or two of the three Akt isoforms was selectively reduced—to explore their specific contributions to tumor induction and invasiveness. They found that growth factor stimulation of the different isoforms led to distinct changes in the abundance of microRNAs, a class of molecules that regulate gene expression and can thereby promote or inhibit oncogenesis. Intriguingly, the effects of Akt signaling on the abundance of the miR-200 family of microRNAs—and thereby on the induction of a metastatic phenotype in human breast cancer cells—appeared to depend on the balance in abundance or activity of Akt1 and Akt2 rather than on overall Akt signaling per se.