Contents
Vol 2, Issue 93
Contents
Editorial Guide
- Focus Issue: Addressing Complicated Questions in Neuroscience
Multiple approaches are needed to understand brain biology and pathology.
Research Articles
- A Noisy Paracrine Signal Determines the Cellular NF-κB Response to Lipopolysaccharide
A low-concentration paracrine TNF-α signal contributes to the variability in NF-κB activation dynamics in the response to lipopolysaccharide.
- Two Mechanistically and Temporally Distinct NF-κB Activation Pathways in IL-1 Signaling
The cooperative activation of NF-κB by two distinct pathways that diverge at TRAF6 critically contributes to the IL-1–dependent inflammatory response.
- STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death
Neurons lacking the calcium sensor STIM2 are protected from hypoxia-induced cell death.
Perspectives
- Emerging Miniaturized Proteomic Technologies to Study Cell Signaling in Clinical Samples
Assessing the state of signaling networks in limited quantity samples may facilitate personalized medical care.
- Schizophrenia: The “BLOC” May Be in the Endosomes
Genetic polymorphisms that affect processes regulated by or participating in endosomal trafficking may increase susceptibility to schizophrenia.
Review
- G Protein–Coupled Receptors, Cholinergic Dysfunction, and Aβ Toxicity in Alzheimer’s Disease
β-amyloid may induce neurodegeneration by affecting G protein–coupled receptor signaling.
Editors' Choice
- Preserving Both Life and Fertility
Imatinib protects oocytes from cisplatin-induced apoptosis.
- Delivering the Wnt Signal
Evi delivers two synaptic mediators required for formation of the neuromuscular junction: transsynaptic Wnt and postsynaptic dGRIP.
- Coupling Clocks and Metabolism
The protein kinase AMPK couples circadian clocks and metabolism in mammals through effects on a cryptochrome protein.
- Subcortical Network Regulation
A form of subcortical control of cortical information processing is mediated by a synaptic release of serotonin and glutamate.
