Contents
Vol 2, Issue 95
Contents
Research Articles
- The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Ciliogenesis
Rfx4 regulates the formation of primary cilia, thereby playing a crucial role in central nervous system development.
- Activation of a Bacterial Virulence Protein by the GTPase RhoA
An enzyme essential for the virulence of Salmonella in mammals is activated by the GTP-bound form of RhoA.
Perspective
- In with the TRP Channels: Intracellular Functions for TRPM1 and TRPM2
Cationic channels of the TRP melastatin family are involved in pigmentation and oxidative stress responses.
Meeting Report
- The Hippo Tumor Suppressor Pathway: A Brainstorming Workshop
Researchers of flies and mammals met to discuss components of the Hippo signaling pathway.
Editors' Choice
- Special Delivery to the Lymph Node
Mast cell–derived particles provide a mechanism for the safe transport of signaling factors from inflamed tissues to the draining lymph nodes.
- Self-Activating, but Still Regulated
Endogenous pseudophosphatases involved in the transition from oocyte to zygote inhibit kinase activity by “substrate trapping.”
- IRF-3 and Ubiquitin
The ubiquitin-conjugating enzyme Ubc5 is required for the activation of interferon regulatory factor 3 during the mitochondrial antiviral response.
- Iron Sensor
A vertebrate hemerythrin domain in an E3 ubiquitin ligase complex senses and regulates cellular iron levels.
- Smells Like a Hormone?
Some odorants can activate nuclear estrogen receptors, as well as cell surface odor receptors.
