In with the TRP Channels: Intracellular Functions for TRPM1 and TRPM2

See allHide authors and affiliations

Science Signaling  03 Nov 2009:
Vol. 2, Issue 95, pp. pe69
DOI: 10.1126/scisignal.295pe69

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Transient receptor potential (TRP) channels are a large family of cation channels, many of which are predominantly localized to the plasma membrane, where they transduce the effects of diverse and often sensory stimuli. Two members of the TRP melastatin subfamily, TRPM1 and TRPM2, are localized in intracellular compartments and are involved in melanin synthesis and oxidative stress–induced cell death, respectively. These findings provide new insight into the location and function of TRP channels.

View Full Text

Stay Connected to Science Signaling

Editor's Blog