17 November 2009
Vol 2, Issue 97

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article describing how tyrosine phosphorylation of pyruvate kinase M2 (PKM2) shifts tumor cell metabolism in a phenomenon known as the Warburg effect and gives them a metabolic advantage. The image (based on PDB 3BJF) shows the crystal structure of PKM2. [Image: Chris Bickel, AAAS]