Contents
Vol 2, Issue 97
Contents
Research Articles
- Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
Tyrosine phosphorylation of pyruvate kinase M2 gives tumor cells a metabolic advantage.
- Trypanosoma cruzi Targets Akt in Host Cells as an Intracellular Antiapoptotic Strategy
A surface protein of the intracellular parasite Trypanosoma cruzi acts both intracellularly and extracellularly to keep infected cells alive.
Perspectives
- PKM2 Tyrosine Phosphorylation and Glutamine Metabolism Signal a Different View of the Warburg Effect
Aerobic glycolysis in cancer cells is associated with tyrosine phosphorylation of a metabolic enzyme.
- Acetylation Goes Global: The Emergence of Acetylation Biology
Proteomic analysis shows protein acetylation to be more prevalent than previously appreciated.
Editors' Choice
- Ensuring Efficient Eating
PPAR-δ in macrophages is required to efficiently clear apoptotic cells and to prevent autoimmune responses.
- Differential Treatment in the ER
Components of the endoplasmic reticulum quality control are involved in immune responses mediated by the plant pattern recognition receptor EFR.
- Arrested Development
An adult-phase diapause protects the germ line of starved nematodes, and pheromone receptors required for a nematode larval-phase diapause are identified.
- Picking a Promoter
Lysine monomethylation of the transcription factor NF-κB affects the stability of its interaction with specific gene promoters.
- Sleep and Alzheimer’s Disease
Sleep patterns can influence amyloid plaque formation in a mouse model of Alzheimer’s disease.
- Outfoxing Immune Excess
Suppressor T cells regulate different classes of immune responses through induction of specific transcription factors.
- The Other Path to Cancer
Activation of an epigenetic switch causes stable cell transformation.
