Contents
Vol 2, Issue 98
Contents
Research Articles
- mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
Rapamycin reverses aging-related declines in hematopoietic stem cell function.
- Eukaryotic Protein Domains as Functional Units of Cellular Evolution
Clustering proteins into groups on the basis of their domain compositions provides insight into protein evolution.
- Ca2+ Puffs Originate from Preestablished Stable Clusters of Inositol Trisphosphate Receptors
Localized calcium signals called Ca2+ puffs arise at preestablished clusters of IP3Rs.
Perspective
- Maintaining Diplomatic Relations Between Mammals and Beneficial Microbial Communities
The adaptive immune system compensates if innate mechanisms fail to contain microbes in the mammalian intestine.
Podcast
- Science Signaling Podcast: 24 November 2009
Bioinformatics analysis reveals how protein domain composition correlates with evolutionary change.
Editors' Choice
- T Cells Get the Nod
Nod2 functions within T cells to promote differentiation into T helper cells.
- Regulatory Neutrophils
Syk- and MyD88-dependent signaling pathways converge to endow mouse neutrophils with regulatory properties.
- Systemic View of Stem Cells
Multiple system-level analyses provide insights into the regulatory events that underlie differentiation of embryonic stem cells.
- PARt of the Response to DNA Damage
PARP-1 promotes the formation of a complex that ultimately leads to NF-κB activation in the DNA damage response.
- Taking Turns Sending and Receiving
Inverse oscillatory recruitment of two signaling components to interacting Neurospora germling cells prevents cells from self-stimulation.
- Dysbindin Function in Synaptic Homeostasis
The dysbindin protein is required for the modulation of presynaptic neurotransmitter release in Drosophila.
- Periplasmic Redox Regulation
A thioredoxin-like enzyme controls the oxidation state of the bacterial periplasm.
