Contents

Contents

• Research Articles

  • mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

    By Chong Chen, Yu Liu, Yang Liu, Pan Zheng

    Science Signaling24 Nov 2009 : ra75 Full AccessRestricted Access

    Rapamycin reverses aging-related declines in hematopoietic stem cell function.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Eukaryotic Protein Domains as Functional Units of Cellular Evolution

    By Jing Jin, Xueying Xie, Chen Chen, Jin Gyoon Park, Chris Stark, D. Andrew James, Marina Olhovsky, Rune Linding, Yongyi Mao, Tony Pawson

    Science Signaling24 Nov 2009 : ra76 Full AccessRestricted Access

    Clustering proteins into groups on the basis of their domain compositions provides insight into protein evolution.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Ca²⁺ Puffs Originate from Preestablished Stable Clusters of Inositol Trisphosphate Receptors

    By Ian F. Smith, Steven M. Wiltgen, Jianwei Shuai, Ian Parker

    Science Signaling24 Nov 2009 : ra77 Full AccessRestricted Access

    Localized calcium signals called Ca²⁺ puffs arise at preestablished clusters of IP₃Rs.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • Maintaining Diplomatic Relations Between Mammals and Beneficial Microbial Communities

    By David A. Hill, David Artis

    Science Signaling24 Nov 2009 : pe77 Full AccessRestricted Access

    The adaptive immune system compensates if innate mechanisms fail to contain microbes in the mammalian intestine.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 24 November 2009

    By Tony Pawson, Annalisa M. VanHook

    Science Signaling24 Nov 2009 : pc21 Full AccessRestricted Access

    Bioinformatics analysis reveals how protein domain composition correlates with evolutionary change.

    • Abstract
    • Full Text

• Editors' Choice

  • T Cells Get the Nod

    By Nancy R. Gough

    Science Signaling24 Nov 2009 : ec375 Full AccessRestricted Access

    Nod2 functions within T cells to promote differentiation into T helper cells.

    • Abstract

  • Regulatory Neutrophils

    By John F. Foley

    Science Signaling24 Nov 2009 : ec376 Full AccessRestricted Access

    Syk- and MyD88-dependent signaling pathways converge to endow mouse neutrophils with regulatory properties.

    • Abstract

  • Systemic View of Stem Cells

    By L. Bryan Ray

    Science Signaling24 Nov 2009 : ec377 Full AccessRestricted Access

    Multiple system-level analyses provide insights into the regulatory events that underlie differentiation of embryonic stem cells.

    • Abstract

  • PARt of the Response to DNA Damage

    By Wei Wong

    Science Signaling24 Nov 2009 : ec378 Full AccessRestricted Access

    PARP-1 promotes the formation of a complex that ultimately leads to NF-κB activation in the DNA damage response.

    • Abstract

  • Taking Turns Sending and Receiving

    By Nancy R. Gough

    Science Signaling24 Nov 2009 : ec379 Full AccessRestricted Access

    Inverse oscillatory recruitment of two signaling components to interacting Neurospora germling cells prevents cells from self-stimulation.

    • Abstract

  • Dysbindin Function in Synaptic Homeostasis

    By Stella M. Hurtley

    Science Signaling24 Nov 2009 : ec380 Full AccessRestricted Access

    The dysbindin protein is required for the modulation of presynaptic neurotransmitter release in Drosophila.

    • Abstract

  • Periplasmic Redox Regulation

    By Stella M. Hurtley

    Science Signaling24 Nov 2009 : ec381 Full AccessRestricted Access

    A thioredoxin-like enzyme controls the oxidation state of the bacterial periplasm.

    • Abstract