Contents
Vol 2, Issue 99
Contents
Editorial Guide
- Living by the Numbers
Articles should be judged on their own merit, not the Impact Factor of the journal in which they are published.
Research Articles
- Protein Kinase G Controls Brown Fat Cell Differentiation and Mitochondrial Biogenesis
PKG regulates differentiation and thermogenic function in brown adipose tissue.
- RIAM Regulates the Cytoskeletal Distribution and Activation of PLC-γ1 in T Cells
RIAM, an adaptor protein that regulates integrin signaling, is found to also function in T cell receptor–proximal signaling.
Protocol
- Quantitative Analysis of Protein-Lipid Interactions Using Tryptophan Fluorescence
The intrinsic fluorescence of tryptophan can be used to quantify the interaction between proteins and lipids.
Podcast
- Science Signaling Podcast: 1 December 2009
Protein kinase G is required for the differentiation and fat-burning function of brown adipose tissue.
Editors' Choice
- Memories of Receptors Endocytosed
Altered phosphorylation of a neurotransmitter receptor leads to specific loss of spatial memory.
- Sealed with a Kinase
G protein βγ subunits stimulate a Fyn-dependent pathway that reverses thrombin-induced permeability of endothelial cells.
- Controlling Synaptogenesis
A protein tyrosine phosphatase binds to cell adhesion proteins through its ectodomain to promote synapse formation.
- Notch and Self-Renewal
PEDF promotes Notch signaling in adult neural stem cells by stimulating the p65-dependent nuclear export of the transcriptional corepressor N-CoR.
- Simply Mycoplasma
A set of comprehensive analyses of the proteome, metabalome, and transcriptome of a relatively simple bacterium reveals insights into signaling, gene regulation, metabolism, and beyond.
