Editors' ChoiceEndocrinology

Steroid Receptors Hit and Run

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Science's STKE  22 Feb 2000:
Vol. 2000, Issue 20, pp. tw3
DOI: 10.1126/stke.2000.20.tw3

In the presence of hormone, steroid receptors modulate transcription by binding to specific response elements in chromatin and recruiting coactivators or corepressors. McNally et al. have observed the interaction of glucocorticoid receptor, labeled with green fluorescent protein, with response elements in living cells. With ligand continuously present, the receptor exchanges rapidly between chromatin and the nucleoplasmic compartment. This finding is inconsistent with the view that the receptor remains bound to chromatin as long as ligand is present. Instead, it supports the "hit and run" mechanism in which the receptor interacts transiently and recruits secondary factors to form a stable complex that modulates transcription.

McNally, J.G., Müller, W.G., Walker, D., Wolford, R., and Hager, G.L. (2000) The glucocorticoid receptor: Rapid exchange with regulatory sites in living cells. Science 287: 1262-1265. [Abstract] [Full Text]

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