Editors' ChoicePhysiology

SOCS is the Heavy

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Science's STKE  04 Jul 2000:
Vol. 2000, Issue 39, pp. tw10
DOI: 10.1126/stke.2000.39.tw10

Some cytokine actions can be thwarted by members of the suppressors of cytokine signaling (SOCS) family. However, when mice lacking SOCS-2 were generated, they did not exhibit any hematological abnormalities, but rather, grew larger in overall size compared with their wild-type littermates; the SOCS2 null adults were 40% heavier than the wild-type. The mass of several organs and body length increased because of an increase in cell number rather than cell size. This phenotype closely resembled that of mice with increased insulin-like growth factor I (IGF-I) production. Metcalf et al. found that the SOCS-2 null mice had increased IGF-I production in several of the enlarged organs and propose that SOCS-2 may be a negative regulator of IGF-I signaling. This supports previous work in cultured cells that reported the inhibitory effect of SOCS-2 on growth hormone signaling.

Metcalf, D., Greenhaigh, C.J., Viney, E., Willson, T.A., Starr, R., Nicola, N.A., Hilton, D.J., and Alexander, W.S. (2000) Gigantism in mice lacking suppressor of cytokine signalling-2. Nature 405: 1069-1073. [Online Journal]

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