Editors' ChoiceImmunology

T Cell Calcium Signaling

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Science's STKE  18 Sep 2001:
Vol. 2001, Issue 100, pp. tw338
DOI: 10.1126/stke.2001.100.tw338

T cell activation triggers the mobilization of calcium from intracellular stores, an event that activates signaling mechanisms including the initiation of protein tyrosine phosphorylation by Src family kinases. Calcium release can occur through activated ryanodine receptors (RyRs), the major intracellular calcium release channels in many tissue types. Guse et al. show that tyrosine phosphorylation of RyRs in activated T cells regulates calcium release. Stimulation of T cell receptors caused transient tyrosine phosphorylation of RyRs. The Src-like kinases Fyn and Lck associated with RyRs isolated from Jurkat T cells, and both kinases phosphorylated isolated RyRs in vitro. However, in permeabilized T cells, only addition of recombinant Fyn enhanced calcium release from activated RyRs.

A. H. Guse, A. Y. Tsygankov, K. Weber, G. W. Mayr, Transient tyrosine phosphorylation of human ryanodine receptor upon T cell stimulation. J. Biol. Chem. 293, 34722-34727 (2001). [Abstract] [Full Text]

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