Editors' ChoiceNeurobiology

Making the Transfer

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Science's STKE  27 Mar 2001:
Vol. 2001, Issue 75, pp. tw13
DOI: 10.1126/stke.2001.75.tw13

The origin and movement of neurotrophic factors such as brain-derived neurotrophic factor (BDNF) between nerve cells has been controversial. Kohara et al. used BDNF tagged with green fluorescent protein to follow anterograde synaptic transport from axons of neurons to postsynaptic cells. This synaptic transport of the growth factor is absent when neuronal activity was blocked by tetrodotoxin and was enhanced after reduction of inhibition. These results constitute direct evidence for an anterograde, trans-synaptic transport of BDNF.

K. Kohara, A. Kitamura, M. Morishima, T. Tsumoto, Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons. Science 291, 2419-2423 (2001). [Abstract] [Full Text]

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