Editors' ChoiceCalcium

Does CaT1 Equal ICRAC?

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Science's STKE  10 Apr 2001:
Vol. 2001, Issue 77, pp. tw7
DOI: 10.1126/stke.2001.77.tw7

The biophysical properties of the calcium-release-activated calcium channel (ICRAC) are well documented; however, the molecular nature of the channel has remained elusive. Although several candidates have been put forth for this capacitative or store-operated calcium channel, none so far has the unique electrophysiological profile of ICRAC (see Putney). Characterization of the biophysical properties of the CaT1 channel when expressed by transfected Chinese hamster ovary cells suggests that CaT1 may be the elusive channel. Yue et al. show the these transfected cells have a highly selective Ca2+ channel with the same ion selectivity, permeability to Na+ in the absence of divalent cations, single-channel conductance characteristics, and activation by depletion of endoplasmic reticulum calcium stores as those reported for ICRAC.

J. W. Putney Jr., Channelling calcium. Nature 410, 648-649 (2001). [Online Journal]

L. Yue, J.-B. Peng, M. A. Hediger, D. E. Clapham, CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature 410, 705-709 (2001). [Online Journal]

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