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Abstract
Although transforming growth factor-β (TGF-β) can affect cell cycle arrest, not much molecular detail is known about how TGF-β-dependent arrest is mediated. Two recent papers shed some light on how this is accomplished. Orian and Eisenman discuss how Myc interacts with Miz-1 to block the expression of a cell cycle inhibitory protein, p15INK4b, and how TGF-β is able to unblock Myc-dependent repression of Miz-1.
