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Abstract
Inhibitor of κB kinase α (IKKα) was originally identified as a component of a multiprotein kinase complex that regulates the activity of the transcription factor nuclear factor-κB (NF-κB) through phosphorylation of its inhibitor proteins, the IκBs. DiDonato discusses new roles that have been discovered for IKKα, focusing especially on its role in epidermal differentiation and on a new function of IKKα in B cell maturation. In epidermal differentiation, IKKα regulates the production of a secreted differentiation factor through a pathway that is independent of its role in activation of NF-κB. In B cell maturation, conventional NF-κB signal-induced activation of IKKα results in phosphorylation of p100 precursor proteins and increased proteolytic processing and constitutive NF-κB activation.
