Fungal Histidine Kinases

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Science's STKE  04 Sep 2001:
Vol. 2001, Issue 98, pp. re1
DOI: 10.1126/stke.2001.98.re1

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Unicellular organisms and cells in higher life forms have signaling pathways by which environmental stimuli are transmitted to cellular machineries that modulate metabolism and mode of growth. Signals are often propagated by the transient phosphorylation of proteins that constitute such intracellular pathways. Like many bacteria, yeast species have cellular pathways in which signaling is achieved by relaying a phosphoryl group from histidine to aspartate residues of proteins. We will discuss recent studies of the "phosphorelay" signaling systems in yeasts and their potential as targets for novel antibiotics.

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