Editors' ChoiceG Protein-Coupled Receptors

Strengthening Blood Vessels

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Science's STKE  04 Sep 2001:
Vol. 2001, Issue 98, pp. tw9
DOI: 10.1126/stke.2001.98.tw9

After an injury, the coagulation cascade goes into action to repair damaged tissue. When coagulation factors are eliminated in mouse embryos, the embryos die at mid-gestation and display extensive bleeding. Whether this is a result of defective platelet function or vascular defects has been unclear. Griffin et al. (see the Perspective by Carmeliet) have addressed this question by examining the role of PAR1, a G protein-coupled receptor that binds to and is cleaved by thrombin, a serine-protease coagulation factor. PAR1 is shown to be an endothelial factor and is needed for normal vascular development and integrity.

C. T. Griffin, Y. Srinivasan, Y.-W. Zheng, W. Huang, S. R. Coughlin, A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 293, 1666-1670 (2001). [Abstract] [Full Text]

P. Carmeliet, Clotting factors build blood vessels. Science 293, 1602-1604 (2001). [Full Text]

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