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Abstract
The intensive effort poured into cancer research over the last 30 years has led to a tremendous increase in our understanding of cancer biology and of the cellular processes whose dysregulation has been implicated in cancer pathogenesis and progression. In many cases, the road to cancer pathogenesis and progression represents a detour from the normal pathways involved in cell signaling. This Focus Issue of Science's STKE highlights cell signaling pathways implicated in various aspects of cancer progression.
