About The Cover

Cover image expansion

COVER This week features a Perspective on the evolution of nuclear receptors that highlights the diversity of this protein family and the recent cloning of a constitutively active estrogen receptor from Aplysia that does not bind ligand. The cover image illustrates the ligand-binding cavity (green) of the PPARγ nuclear receptor. [Image: John W. R. Schwabe and Sarah A. Teichmann, MRC-Laboratory of Molecular Biology, Cambridge, UK.]