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Contents

23 March 2004
Vol 2004, Issue 225

Contents
- Editorial Guide
  - Focus Issue: Targeting Signaling Pathways for Drug Discovery
    
    By Nancy R. Gough, Elizabeth M. Adler, L. Bryan Ray
    
    Science's STKE23 Mar 2004 : eg5 Full AccessRestricted Access
    
    Abstract
    
    Full Text
    
    PDF
- Perspectives
  - Gleevec: Prototype or Outlier?
    
    By William G. Kaelin Jr.
    
    Science's STKE23 Mar 2004 : pe12 Full AccessRestricted Access
    
    Abstract
    
    Full Text
    
    PDF
  - Methotrexate and Ras Methylation: A New Trick for an Old Drug?
    
    By Mark R. Philips
    
    Science's STKE23 Mar 2004 : pe13 Full AccessRestricted Access
    
    Abstract
    
    Full Text
    
    PDF
  - Accessing Natural Products by Combinatorial Biosynthesis
    
    By Ben Shen
    
    Science's STKE23 Mar 2004 : pe14 Full AccessRestricted Access
    
    Abstract
    
    Full Text
    
    PDF
- Review
  - Life Stress, Genes, and Depression: Multiple Pathways Lead to Increased Risk and New Opportunities for Intervention
    
    By Dennis S. Charney, Husseini K. Manji
    
    Science's STKE23 Mar 2004 : re5 Full AccessRestricted Access
    
    Abstract
    
    Full Text
    
    PDF
- Editors' Choice
  - TRP Channels Control Serotonin Synthesis
    
    Science's STKE23 Mar 2004 : tw108-TW108 Full AccessRestricted Access
    
    Abstract

About The Cover

Cover image expansion

COVER This Focus Issue features an Editorial Guide on drug development and signaling molecules as therapeutic targets. The image depicts a pharmaceutical agent designed to specifically inhibit a protein kinase. [Image: M.E.M Noble, J. A. Endicott, L. N. Johnson]