Contents

Contents

• Editorial Guide

  • Focus Issue: Targeting Signaling Pathways for Drug Discovery

    By Nancy R. Gough, Elizabeth M. Adler, L. Bryan Ray

    Science's STKE23 Mar 2004 : eg5 Full AccessRestricted Access

    • Abstract
    • Full Text
    • PDF

• Perspectives

  • Gleevec: Prototype or Outlier?

    By William G. Kaelin Jr.

    Science's STKE23 Mar 2004 : pe12 Full AccessRestricted Access

    • Abstract
    • Full Text
    • PDF

  • Methotrexate and Ras Methylation: A New Trick for an Old Drug?

    By Mark R. Philips

    Science's STKE23 Mar 2004 : pe13 Full AccessRestricted Access

    • Abstract
    • Full Text
    • PDF

  • Accessing Natural Products by Combinatorial Biosynthesis

    By Ben Shen

    Science's STKE23 Mar 2004 : pe14 Full AccessRestricted Access

    • Abstract
    • Full Text
    • PDF

• Review

  • Life Stress, Genes, and Depression: Multiple Pathways Lead to Increased Risk and New Opportunities for Intervention

    By Dennis S. Charney, Husseini K. Manji

    Science's STKE23 Mar 2004 : re5 Full AccessRestricted Access

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • TRP Channels Control Serotonin Synthesis

    Science's STKE23 Mar 2004 : tw108-TW108 Full AccessRestricted Access

    • Abstract