Editors' ChoiceNEUROPEPTIDES

Alert But Not Anxious with NPS

See allHide authors and affiliations

Science's STKE  24 Aug 2004:
Vol. 2004, Issue 247, pp. tw298
DOI: 10.1126/stke.2472004tw298

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Compose eLetter

Plain text

  • Plain text
    No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests
CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Image CAPTCHA
Enter the characters shown in the image.

Vertical Tabs

  • RE: NPS not indicated for pharmacological use

    Mr. Spector,
    I think you may have misinterpreted the rationale for comparing the neuropeptide NPS to nicotine in the summary of the article and in the highlighted article. Many drugs act on proteins or targets to mimic or inhibit the effects of naturally occurring molecules in the body. I think the authors of the highlighted article (Xu et al.) made the comparison to nicotine as to indicate that NPS seemed to trigger similar responses, albeit through a different receptor than nicotine targets. Whether this receptor for NPS or the neuronal circuits activated by this neuropeptide signal could be exploited to produce anti-anxiety medications without the addictive properties of nicotine remain to be determined. The highlighted study was performed in rodents, which may respond very differently to NPS than humans do. The editors at Science's STKE who highlighted these findings did not intend to imply that NPS should become used in humans as a stimulant or treatment of mood-related disorders, but that Xu et al. had identified an endogenous neuropeptide and its receptor, signaling through which had both alertness-promoting effects without anxiety-promoting effects.

    Competing Interests: None declared.
  • RE: Alert But Not Anxious with NPS

    The article proposes use of NPS to highten alertness without also stimulating anxiety and compares NPS with nicotine, but does not seem to address the question of addiction. Nicotine is addicting, to a point that makes it a public health hazard. Is NPS similarly addicting?

    Competing Interests: None declared.