From Gene Expression Patterns to Function

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Science's STKE  21 Sep 2004:
Vol. 2004, Issue 251, pp. tw335
DOI: 10.1126/stke.2512004tw335

One goal of microarray approaches is to map patterns of linked gene expression with function. Ao et al. used an algorithm to establish clusters of genes expressed in different pharyngeal cell types to identify five cis-regulatory elements with biological activity within the foregut of Caenorhabditis elegans. The protein DAF-12 binds one of these elements to modulate the response to food availability. A large dataset of putative foregut genes is processed to identify a transcription factor and its binding site and to show physiological conditions under which this factor works.

W. Ao, J. Gaudet, W. J. Kent, S. Muttumu, S. E. Mango, Environmentally induced foregut remodeling by PHA-4/FoxA and DAF-12/NHR. Science 305, 1743-1746 (2004). [Abstract] [Full Text]

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