Editors' ChoiceCell Adhesion

Variation on a Theme

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Science's STKE  18 Jan 2005:
Vol. 2005, Issue 267, pp. tw30
DOI: 10.1126/stke.2672005tw30

The semaphorins and their plexin-neuropilin coreceptors are established players in axon guidance. More recently, they have also been implicated in vascular development. Gu et al. report that semaphorin 3E (Sema3E) does not require neuropilin as a coreceptor in patterning the developing mouse vascular system but instead interacts directly with the plexin-D1-expressing cells. The repulsive effect of Sema3E-bearing somites on vascular endothelial cells expressing plexin-D1 was observed in the absence of neuropilins, which indicates that neuropilins are not, after all, obligatory semaphorin coreceptors in mammalian vasculogenesis.

C. Gu, Y. Yoshida, J. Livet, D. V. Reimert, F. Mann, J. Merte, C. E. Henderson, T. M. Jessell, A. L. Kolodkin, D. D. Ginty, Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science 307, 265-268 (2005). [Abstract] [Full Text]

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