Editors' ChoiceVirology

Cytokine Production and Kaposi's

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Science's STKE  08 Feb 2005:
Vol. 2005, Issue 270, pp. tw60
DOI: 10.1126/stke.2702005tw60

When tissues are infected with Kaposi's sarcoma-associated herpesvirus (KSHV), they produce large amounts of pro-inflammatory cytokines that are linked to disease progression. McCormick and Ganem show that a viral protein, kaposin B, interacts with mitogen-activated protein kinase-associated protein kinase 2 and enhances the activity of this host-cell protein, serving to block the decay of AU-rich messenger RNAs and increase the level of secreted cytokines. This result explains the association of KSHV-related disease and enhanced cytokine production.

C. McCormick, D. Ganem, The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs. Science 307, 739-741 (2005). [Abstract] [Full Text]

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