Editors' ChoiceDevelopment

Who Regulates the Regulators?

See allHide authors and affiliations

Science's STKE  01 Nov 2005:
Vol. 2005, Issue 308, pp. tw388
DOI: 10.1126/stke.3082005tw388

In plants, the shoot apical meristem is a group of stem cells at the shoot tip that generate the various differentiated tissues of the vegetative aboveground plant. Reddy and Meyerowitz have analyzed how the meristem in Arabidopsis is maintained at a particular size, despite cells being continually diverted to differentiation pathways. The results indicate that the CLAVATA3 gene product and its resultant signaling network control the number of cells in the meristem by effects on both cell proliferation and cellular fates during differentiation.

G. V. Reddy, E. M. Meyerowitz, Stem-cell homeostasis and growth dynamics can be uncoupled in the Arabidopsis shoot apex. Science 310, 663-667 (2005). [Abstract] [Full Text]

Stay Connected to Science Signaling