Editors' ChoiceImmunology

A Gut Oxidase Reaction

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Science's STKE  08 Nov 2005:
Vol. 2005, Issue 309, pp. tw399
DOI: 10.1126/stke.3092005tw399

The mucosal surfaces of the body are constantly exposed to microorganisms and have evolved a variety of protective innate immune mechanisms, including the generation of antimicrobial peptides throughout the animal kingdom. Another hallmark of the innate immune response is the generation of microbicidal reactive oxygen species (ROS) by phagocytes. Ha et al. observe that gut mucosal epithelial cells of Drosophila expressed dual oxidase (dDuox) upon bacterial infection. Flies in which dDuox expression had been silenced were significantly more susceptible to infection, and protection could be restored upon dDuox reexpression. Similar mucosal ROS production mechanisms may be exploited in host defense across different species.

E.-M. Ha, C.-T. Oh, Y. S. Bae, W.-J. Lee, A direct role for dual oxidase in Drosophila gut immunity. Science 310, 847-850 (2005). [Abstract] [Full Text]

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