The Significance of Interferon-γ–Triggered Internalization of Tight-Junction Proteins in Inflammatory Bowel Disease

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Science's STKE  03 Jan 2006:
Vol. 2006, Issue 316, pp. pe1
DOI: 10.1126/stke.3162006pe1

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Disruption of the epithelial barrier function of tight junctions by the proinflammatory cytokine interferon (IFN)–γ plays a fundamental role in the pathogenesis of inflammatory bowel disease and other gastrointestinal disorders, but its precise mechanism has not been established. This Perspective provides an overview of how IFN-γ triggers barrier dysfunction and bacterial translocation in intestinal epithelial cells, and highlights the roles of internalization of tight-junction transmembrane proteins, as well as rearrangements of the cortical actin cytoskeleton, in intestinal inflammation.

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