Inter- and Intrachromosome Interactions in Gene Regulation

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Science's STKE  18 Apr 2006:
Vol. 2006, Issue 331, pp. tw134
DOI: 10.1126/stke.3312006tw134

Long-range interactions within chromosomes that occur through intrachromosomal loops can set up important gene regulatory interactions. For example, the imprinting control region (ICR) at the insulin-like growth factor 2 (Igf2)/H19 locus on mouse chromosome 7 is involved in bringing distant enhancers into promoter regions to increase gene transcription. Ling et al. (see the Perspective by Spilianakis and Flavell) now show that interchromosome as well as intrachromosome interactions are mediated throughout the Igf2/H19 ICR. The maternal Igf2/H19 ICR interacts with a specific region on paternal chromosome 11. This interaction requires an ICR binding protein and appears to play a role in the regulation of expression of the interacting genes on chromosome 11.

J. Q. Ling, T. Li, J. F. Hu, T. H. Vu, H. L. Chen, X. W. Qiu, A. M. Cherry, A. R. Hoffman, CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1. Science 312, 269-272 (2006). [Abstract] [Full Text]

C. G. Spilianakis, R. A. Flavell, Managing associations between different chromosomes. Science 312, 207-208 (2006). [Summary] [Full Text]

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