The actin cytoskeleton regulates many aspects of cellular and organismal biology. Coronins have been implicated in the regulation of cytoskeletal dynamics. Föger et al. (see the Perspective by Dustin) focused on understanding the in vivo functions of the actin-binding protein coronin 1. Coronin 1 was required for chemokine-mediated migration of immune cells and for organizing cytoskeletal changes.
N. Föger, L. Rangell, D. M. Danilenko, A. C. Chan, Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science 313, 839-842 (2006). [Abstract] [Full Text]
M. L. Dustin, When F-actin becomes too much of a good thing. Science 313, 767-768 (2006). [Summary] [Full Text]
