Contents
Vol 2006, Issue 353
Contents
Perspective
- Cross-Linking Transglutaminases with G Protein–Coupled Receptor Signaling
Transglutaminases use multiple mechanisms to regulate G protein-coupled receptors.
Protocol
- Simultaneous Optical Measurements of Cytosolic Ca2+ and cAMP in Single Cells
FRET biosensors can be combined with Fura-2 to investigate interactions between Ca2+ and cAMP signaling.
Editors' Choice
- Irrelevant Apoptosis?
Does p53 suppress tumors independent of the apoptotic response to DNA damage?
- Promoting Regeneration Rather Than Death?
The tumor suppressor p53 promotes neurite outgrowth and neuronal regeneration.
- Challenging the JNK2 Knockout Data
Chemical genetics data suggest that JNK2 is a redundant activator, not inhibitor, of the JNK pathway.
- Caveolin and Liver Regeneration
Mice lacking a protein that helps cells internalize other proteins and signaling molecules seem to be normal, but their livers cannot regenerate after being damaged.
- Endocytotic Function for Syntaxin 1A
Syntaxin functions in neuronal endocyctosis as well as exocytosis.
- Phosphatidylserine Recruits Rac1
Rac1 stimulates cell migration through interactions of its polybasic motif with plasma membrane phosphatidylserine.
- How Nickel Binding Regulates Transcription
Crystal structures show how metal ion binding alters protein structure to control gene transcription.
- Identifying the CRAC Channel
Two groups use mutational analysis to identify Orai as the Ca2+ release-activated Ca2+ channel pore subunit.
- Of Aging and Aggregation
The insulin/insulin-like receptor pathway can detoxify protein aggregates in worms engineered to express excess protein in their muscles, perhaps partly explaining its role in aging.
