Contents
Vol 2006, Issue 354
Contents
Perspectives
- Tumor Suppression by p53 Is Mediated in Part by the Antiangiogenic Activity of Endostatin and Tumstatin
p53 inhibits not only tumor cell proliferation and survival but also tumor angiogenesis.
- Advances in Understanding Brassinosteroid Signaling
Plants use plasma membrane receptor complexes to trigger the response to steroid hormones.
- mRNA Regulation by Puf Domain Proteins
How do Puf domain proteins regulate mRNA and what are their targets?
Editors' Choice
- Pore-Forming Pathogens Activate the Inflammasome
Caspase 1 promotes membrane repair in response to pathogens.
- A Second Wind for T Cells
Inhibitory cell surface receptor PD-1 is implicated in T cell "exhaustion" during chronic HIV infection.
- Disulfide Switch Alters Receptor Signals
A disulfide bond acts as a switch in control of blood coagulation.
- From Myc Activation to Angiogenesis
Myc stimulates IL-1β secretion to stimulate endothelial cell proliferation and tubulogenesis.
- Polarizing Neurons
DOCK 7 regulates axon formation by means of Op18 regulation of microtubule dynamics.
- Inhibition of PIP5K by Apoptotic Stresses
Oxidative stress and ultraviolet radiation promote phosphorylation of PIP5K, which prevents resynthesis of PI(4,5)P2 and leads to cell death.
- Tanning in the Dark?
Activation of cAMP signaling downstream of MC1R elicits eumelanin production and protects against skin damage.
- Beyond Self-Nonself for MHC
A molecule that is usually thought of as a hallmark of the immune system interacts with a receptor in the brain to limit the plasticity of the visual system during development.
- Protein Pathways in Epilepsy
Proteins linked to a particular epilepsy syndrome are found to work together at brain synapses.
- Social Experience and the Need to Sleep
The complexity and intensity of social interaction, information gleaned during prior waking, or both stably change sleep patterns in Drosophila.
