Contents
Vol 2006, Issue 355
Contents
Editorial Guide
- Focus Issue: From Genes to Tissues
Complex regulatory networks allow genes to specify complex organisms.
Perspectives
- Variations on a Theme: Hox and Wnt Combinatorial Regulation During Animal Development
Hox proteins and Wnt signaling jointly induce subordinate genes required to establish cell or tissue identity.
- MAPping Out Arteries and Veins
Recent research implicates the MAPK pathway in promoting arterial fate.
- Gene Control by Large Noncoding RNAs
New studies implicate large noncoding RNAs in the control of gene transcription.
Editors' Choice
- Staying Young with p16INK4a
The cyclin-dependent kinase inhibitor p16INK4a appears to play a role in aging-related loss of progenitor cell proliferation and regenerative capacity.
- Pruning a Dendritic Tree
Dendritic pruning of ddaC during metamorphosis depends on localized caspase activation.
- Translating Cues into Action
Asymmetric localization and translation of β-actin is involved in growth cone turning.
- TAO2 Directs TAK1 to JNK
TAO2 prevents TAK1 from activating NF-κB in response to osmotic stress.
- Stop to Start
A protein responsible for preventing unwanted immune responses discourages extended liaisons between activated immune cells.
- Sweet Smell of Communication
A parasitic plant locates a preferred host by detecting its released odors; disrupting this process could help control parasites of crop plants.
- Mapping Biological Connectivity
Comparison of mRNAs evoked by small molecules in human cells to mRNA expressed in diseases and in response to drugs suggests new therapeutic approaches.
- Muscle Building
An inherited muscle disease in which certain muscles are weak is caused by mutations in a protein needed for proper formation of the neuromuscular junction.
