Contents
Vol 2006, Issue 356
Contents
Editorial Guide
- Focus Issue: Exciting Times for Signaling in the Brain
Glutamate receptors are central to brain function and pathology.
Perspective
- D-Serine Regulation of NMDA Receptor Activity
Does D-serine released from neurons and glia play distinct roles in regulating NMDA receptor activity?
Reviews
- A Unified Model of the Presynaptic and Postsynaptic Changes During LTP at CA1 Synapses
A structural model for LTP accounts for seemingly contradictory results.
- Molecular Signaling Mechanisms Underlying Epileptogenesis
Does increased calcium in dendritic spines play a key role in epileptogenesis?
Editors' Choice
- Tale of Two Two-Timing Proteins
A transcription factor has an additional, apparently unrelated cytoplasmic function regulating the insertion of calcium channels into the plasma membrane.
- More Regulation for FOXO
A new layer of regulation is discovered for a transcription factor implicated in aging and cancer.
- A Mysterious Mechanism for Promoting Anion Conductance
The cleavage products of mClCA3 do not themselves seem to form a transmembrane anion channel.
- Channeling Local Translation
The synthesis of a potassium channel is decreased by neuronal activity near synapses of hippocampal cells, providing a local feedback circuit.
- Anxious Mice and Men
Mice carrying a neurotransmitter with one defective amino acid display memory and mood problems similar to those of humans with the same variant.
- New Substrates for Factor Inhibiting HIF
Ankyrin repeat domains of several proteins appear to undergo asparaginyl hydroxylation.
- XIAP as a Positive Feedback Regulator of Caspase Activation
Modeling of the core intrinsic apoptosis pathway reveals multiple contributors to the bistability of the response.
- Keep It Moving
An unconventional form of long-tailed myosin regulates the adhesion proteins of immune cells, explaining the immunological defects in mice lacking this protein.
