31 October 2006
Vol 2006, Issue 359
  • Contents

    • Review

    • Editors' Choice

      • TLR8 in the Developing Mouse Nervous System

        A Toll-like receptor signaling through a noncanonical pathway negatively regulates neurite growth and stimulates neuronal apoptosis.

      • Removing Proinflammatory Signals

        Macrophage engulfment of late apoptotic immune cells that have abundant CCR5, which binds proinflammatory chemokines, contributes to resolution of inflammation.

      • Deadly Redundancy

        Mouse cells have an alternative cell death pathway mediated by permeabilization of lysosomes.

      • Fungal Gib2, an Atypical Gβ Subunit

        A fungal RACK1 homolog, Gib2, with a seven-bladed β propeller structure serves as the β subunit in G protein signaling.

      • Herding Olfactory Axons

        Guidance of developing olfactory neurons depends on cAMP to signal an approximate position at which the axons will find their target glomeruli.

      • Formation of Ion Channel Complexes

        Large-conductance Ca2+- and voltage-activated K channels (BKCa channels) from brain can be found forming complexes with all three major voltage-gated Ca2+ channels.

      • Alzheimer’s Enzyme and Myelination

        An enzyme that cleaves the precursor of the amyloid peptide that accumulates in Alzheimer's disease unexpectedly also regulates the myelination of nerves.

      • Ring Around the Spindle Checkpoint

        Centrosomal proteins are important for cell cycle progression, but their role does not require their presence in the centrosome itself.

About The Cover

Cover image expansion

COVER This week features a Review that discusses the role of palmitoylation in signal transduction. The image shows the T cell receptor complex and associated proteins (palmitate is shown in yellow). [Image: Christopher Bickel, AAAS]