Contents
Vol 2006, Issue 360
Contents
Perspective
- Stress-ING Out: Phosphoinositides Mediate the Cellular Stress Response
Stress leads to accumulation of the nuclear phosphoinositide PI5P, which in turn recruits the transcription factor ING2 to chromatin.
Editors' Choice
- Channel to the Nucleus?
Does the proteolytically cleaved C terminus of Cav1.2 translocate to the nucleus to act as a transcription factor?
- A Complex Mode of Glucose Signaling
A nucleus-specific hexokinase 1 complex is critical to glucose-mediated regulation of gene transcription.
- OK, Everyone Keep Quiet
Presynaptic glutamate transporters inhibit transmitter release in neighboring retinal rod bipolar cells.
- Neurite Extension and Membrane Trafficking
A protein named protrudin promotes membrane trafficking during neurite extension.
- Donning the Myelin Sheath
A cell polarity protein aids formation of myelination at the junction between Schwann cell and axon.
- Transferrin Receptor 2 as a Signaling Receptor
TfR2 is localized in lipid rafts and exosomes, and binding of transferrin triggers activation of extracellular signal-regulated kinase.
- Probed Isoelectric Focusing for Quantifying Phosphorylated Proteins
Photochemical immobilization of proteins onto capillary walls following isoelectric focusing improves protein detection sensitivity.
- A Cool Way to a Long Life
Transgenic mice engineered to have a 0.5°C reduction in their core body temperature live about 15 percent longer than their wild-type littermates.
Erratum
