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Abstract
This week’s issue of Science’s STKE complements the special issue of Science featuring the Sea Urchin Genome. With new insights gleaned from the 814-Mb genome of the California purple sea urchin Strongylocentrotus purpuratus and its estimated 23,000 genes, this organism holds many secrets to help us understand cell signaling and the evolution of regulatory systems in biology. Two STKE Perspectives discuss signal transduction during early development in the sea urchin.