21 November 2006
Vol 2006, Issue 362
  • Contents

    • Perspectives

    • Editors' Choice

      • Activating Gene Expression

        Small noncoding RNAs may activate the expression of target genes.

      • Fat But Healthy

        A chemical found in red wine prevents diseases and accelerated aging-associated obesity in mice.

      • Shedding Light on Immunosuppression

        Stimulation of a serotonin receptor may underlie the immunosuppressive effects of UV radiation.

      • From Ras to PI3K

        Ras promotes the maximal activation of phosphoinositide 3-kinase in flies and neutrophils.

      • Directing the Mucosal Immune Response

        Immune cells in the gut are programmed by other cells in the nearby lymphoid tissue and a vitamin A-related signal to make antibodies that protect against gut pathogens.

      • Sorting, Signaling, and Sara

        As cells divide during development, daughter cells retain the growth signals received by their parents through equal partitioning of a subpopulation of tagged intracellular vesicles.

About The Cover

Cover image expansion

COVER This week features a Perspective on ubiquitylation and neddylation of the epidermal growth factor receptor in receptor endocytosis. The image depicts ubiquitin and the ubiquitin-like protein NEDD8. [Image: Christopher Bickel, AAAS]