Contents
Vol 2006, Issue 364
Contents
Editorial Guide
- Signal Reception and Transmission
New pathways and updates to the Database of Cell Signaling highlight how signals received at the surface are transmitted into the cell to mediate complex cellular responses.
Editors' Choice
- Connecting Senescence to DNA Damage Response
Two groups report that oncogene-induced senescence involves DNA hyperreplication and the DNA damage response.
- Stimulating Phagocytosis
IgG signaling stimulates interactions between phagosomes and lysosomes.
- A Painful Endogenous Opioid
By stimulating spinal cord bradykinin receptors, dynorphin A contributes to neuropathic pain.
- DANGER, New Regulator of IP3R Calcium-Release Channel
An IP3 receptor-binding protein enhances sensitivity of the Ca2+ release channel to feedback inhibition by Ca2+.
- Startled by a Lack of Zn2+ (Modulation)
Mice with mutated glycine receptors that cannot be potentiated by zinc show that zinc is important for controlling neuromotor function.
- Turn on the PIPs
Neurotransmitters close a potassium channel by changing the lipid content of the surrounding plasma membrane.
- Progesterone and Breast Cancer
Experiments in mice suggest that a mutation leading to breast cancer acts in part by altering signaling by the steroid hormone progesterone.
- Of Genes and Gut Reactions
People with a rare sequence variant of the gene encoding the receptor for an immunological cytokine have a reduced risk of inflammatory bowel disease.
- Turing Patterning in the Mouse Hairs
Modeling and experimental tests explain how a growth factor and its inhibitor determine the density and pattern of hair follicles in the developing mouse.
Connections Map Overviews
- Brassinosteroid Signaling Pathway
Brassinosteroids bind plasma membrane leucine-rich repeat-receptor serine/threonine kinases to ultimately regulate activity of a plant-specific family of transcription factors.
- Arabidopsis Brassinosteroid Signaling Pathway
The molecular mechanisms underlying the plant response to the steroid hormone, brassinosteroid, are elucidated in Arabidopsis thaliana.
- Pheromone Signaling Pathways in Yeast
New data reveals a critical role for G α signaling in this yeast pathway.
- Notch Signaling Pathway
Notch signaling contributes to binary cell-fate decisions.
