05 December 2006
Vol 2006, Issue 364
  • Contents

    • Editorial Guide

      • Signal Reception and Transmission

        New pathways and updates to the Database of Cell Signaling highlight how signals received at the surface are transmitted into the cell to mediate complex cellular responses.

    • Editors' Choice

      • Stimulating Phagocytosis

        IgG signaling stimulates interactions between phagosomes and lysosomes.

      • A Painful Endogenous Opioid

        By stimulating spinal cord bradykinin receptors, dynorphin A contributes to neuropathic pain.

      • Startled by a Lack of Zn2+ (Modulation)

        Mice with mutated glycine receptors that cannot be potentiated by zinc show that zinc is important for controlling neuromotor function.

      • Turn on the PIPs

        Neurotransmitters close a potassium channel by changing the lipid content of the surrounding plasma membrane.

      • Progesterone and Breast Cancer

        Experiments in mice suggest that a mutation leading to breast cancer acts in part by altering signaling by the steroid hormone progesterone.

      • Of Genes and Gut Reactions

        People with a rare sequence variant of the gene encoding the receptor for an immunological cytokine have a reduced risk of inflammatory bowel disease.

      • Turing Patterning in the Mouse Hairs

        Modeling and experimental tests explain how a growth factor and its inhibitor determine the density and pattern of hair follicles in the developing mouse.

    • Connections Map Overviews

About The Cover

Cover image expansion

COVER This week's Focus Issue, published in conjunction with the Science Special Issue on cell signaling, contains an Editorial Guide highlighting new pathways and updates to the Database of Cell Signaling. The image depicts signals emanating from cell surface receptors. [Image: Christopher Bickel, AAAS]