12 December 2006
Vol 2006, Issue 365
  • Contents

    • Perspectives

    • Editors' Choice

      • Serine Acylation of Wnt

        Secretion of mouse Wnt proteins appears to require acylation of a specific serine with the monounsaturated fatty acid, palmitoleic acid.

      • Klotho Gets Around

        Another function for Klotho, a protein implicated in life-span regulation, may be to interact with fibroblast growth factor receptors to adjust the receptor’s specificity.

      • IRS Cancer Connection

        IRS-1 and IRS-2 play different roles in cancer progression.

      • Regulatory RNAs

        When bacteria are starved, a small RNA inhibits transcription by folding to mimic a legitimate promoter target, after which adding nucleotides can restart transcription.

      • From Oscillations to Patterning

        The segmentation clock, which forms repeated body structures during development, generates many oscillating RNAs that regulate common developmental pathways.

      • Understanding the Master Regulator

        Activation of a two-component signaling pathway required for Salmonella virulence triggers a burst of transcription that may allow rapid adaptation to new conditions.

About The Cover

Cover image expansion

COVER This week features a Perspective on the functions of the Oskar mRNA during Drosophila oogenesis. The image depicts the Oskar mRNA and Staufen protein localizing to the posterior of the developing oocyte. [Image: Christopher Bickel, AAAS]