Editors' ChoiceDevelopmental Biology

From Oscillations to Patterning

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Science's STKE  12 Dec 2006:
Vol. 2006, Issue 365, pp. tw421
DOI: 10.1126/stke.3652006tw421

During early vertebrate development, blocks of mesodermal tissue, somites, are laid down on either side of the notochord in a periodic fashion following rhythmic waves of gene expression in the presomitic mesoderm. The somites subsequently give rise to skeletal muscle, axial skeleton, and part of the dermis. Dequéant et al. use a systematic analysis of genes expressed in the presomitic mesoderm over time. Oscillations of the fibroblast growth factor and Notch pathways alternated with components of the Wnt pathway, which suggests that an antagonism between these signaling pathways leads to the generation of phased somites.

M.-L. Dequéant, E. Glynn, K. Gaudenz, M. Wahl, J. Chen, A. Mushegian, O. Pourquié, A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science 314, 1595-1598 (2006). [Abstract] [Full Text]

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