Contents
Vol 2007, Issue 367
Contents
Editorial Guide
- 2006: Signaling Breakthroughs of the Year
Signaling breakthroughs included molecules and processes both outside cells and inside cells, from channels in the membrane to chromatin in the nucleus.
Review
- How Do MicroRNAs Regulate Gene Expression?
Researchers are closing in on mechanisms that allow microRNAs to control stability and translation of mRNAs.
Editors' Choice
- Are Microbial Swords Really Plowshares?
Antibiotics may be used as intermicrobial signaling molecules instead of in competition.
- Cathepsins Sculpt Toes
Lysosomal enzymes contribute to programmed cell death during digit formation.
- Excessive Angiogenesis Inhibits Tumor Growth
Notch signaling inhibits nonproductive blood vessel formation in tumors.
- Asymmetric Turning Mechanisms
Attractive—but not repulsive—growth cone turning appears to depend on asymmetric vesicle trafficking and exocytosis.
- News on Networking
Proteins with many simultaneous partners tend to be conserved, whereas those with one partner at a time are more likely to vary among species.
- Details Define Double Duty
A dual-function protein switches from its compact enzymatic form to an extended RNA binding form through extensive domain rearrangements.
- What's in a Vaccine?
Adjuvants added to vaccines boost responses, surprisingly, without acting through known innate immunity receptors, which indicates a need for vaccine development strategies.
