09 January 2007
Vol 2007, Issue 368
  • Contents

    • Editors' Choice

      • It Takes Two to Sense CO2

        Coexpression of two "gustatory receptors" is required for CO2 detection in Drosophila.

      • Subverting the Histone Code

        Shigella OspF blocks phosphorylation of histone H3 to prevent activation of specific genes involved in the immune response.

      • Saved from Proteolysis

        Erythropoietin protects differentiating erythroid cells from apoptosis by promoting nuclear localization of Hsp70.

      • Connecting GPCRs to NF-κB

        A common adaptor complex couples diverse receptors to activation of NF-κB.

      • Inhibiting Osteoclast Formation

        The extracellular matrix component hyaluronan inhibits formation of bone resorptive cells by activating the Toll-like receptor TLR4.

      • How Do TrkA and p75 Interact?

        Do functional interactions between p75 and TrkA depend on downstream signaling rather than ternary complexes?

      • Cellular Mechanics Up Close and Personal

        Adhesions on a cell membrane act as molecular clutches to transmit forces from the actin cytoskeleton within a cell to the extracellular substrate, directing cell movement.

      • Cellular Accounting

        A microfluidic device captures cells, lyses them, and separates their contents, allowing naturally fluorescent and labeled proteins in a single cell to be counted.

      • Enzyme Kinetics in Living Color

        Fluorescence imaging microscopy can distinguish enzyme molecules within a single cell that are actively involved in signaling versus ones that are being deactivated.

      • Giving Lotus the Nodule

        In the legume Lotus, symbiotic, nitrogen-fixing bacteria induce formation of the root nodules in which they reside by eliciting a growth response from the plant itself.

      • Choosing the Right Path

        Two different types of dendritic cells in the immune system present antigen in different ways to elicit distinct immune responses.

About The Cover

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COVER Join any of the ongoing discussions in the Forums. Comments were recently posted to the Open Forum on Cell Signaling and the forum called Questions and Controversies in Zinc Signaling. [Image: Christopher Bickel, AAAS]