Editors' ChoiceImmunology

Applying the Brakes to the Immune Response

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Science's STKE  23 Jan 2007:
Vol. 2007, Issue 370, pp. tw28
DOI: 10.1126/stke.3702007tw28

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  • Breaking T Cell Activation by IKKbeta

    We have published that IKKβ phosphorylates Bcl10 on a different site [Wegener et al., Mol Cell 23, 13-23 (2006)]. We have identified five serine residues in the C-terminus of Bcl10 (Ser 134, 136, 138, 141, 144) that are phosphorylated by IKKβ. In our analysis, we found no evidence that IKKβ triggers Bcl10 degradatio...

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    Competing Interests: None declared.

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