Contents
Vol 2007, Issue 371
Contents
Perspectives
- EGFR Signaling Inhibits E2F1-Induced Apoptosis in Vivo: Implications for Cancer Therapy
Insights from regulation of cell death during fly development offer clues to potential cancer therapy.
- Split Personality of Transcription Factors Inside and Outside the Nuclear Border
Three transcription factors act outside the nucleus to regulate calcium homeostasis.
Editors' Choice
- Small GTPase Rac Links Receptors to cGMP Formation
Guanylyl cyclase is allosterically activated by GTPase-activated kinase PAK.
- More Than One Way to Signal
High concentrations of β2-AR agonist appear to activate a second, G protein-independent, pathway.
- A New Way to Make Filopodia?
A catalytically inactive lipid-phosphatase-related protein may provide a new mechanism for the formation of these slender cellular protrusions.
- Making the Gradient
The kinetic parameters that establish and maintain morphogenetic gradients are defined and measured for two key morphogens in Drosophila.
- Inside B Cell Central
During selection of immune cells that make high-affinity antibodies within lymph nodes, the cells are highly mobile and seem to compete for help from other immune cells.
- Exploiting Your Niche
In the process of producing differentiating daughters, the mother centrosome of Drosophila male germ cells is anchored via a microtubule array near the niche, producing asymmetric division.
